Endosulfan Causes DNA Damage in Animals: Study (Download PDF)

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First time, researchers in India have found that mice and rats exposed to endosulphan suffer from DNA damage and genomic instability and reduced DNA damage response. The research has been made available by a team of researchers led by Prof. Sathees Raghavan from the Department of Biochemistry, IISc, Bengaluru.

Highlights of Research:

Study the Endosulfan Causes DNA Damage in Animals
  • This research shows that endosulfan - an organochlorine pesticide.
  • it՚s includes breaks in DNA strands and disturbs the damage response mechanism. This found in cells thus leading to compromised DNA component repair.
  • The researcher team found the mice and rats exposed to endosulfan generated reactive oxygen species, effective DNA damaging agent.
  • The broken DNA elements generally tend to repair themselves by rejoining.
  • Non-homologous end joining (NHEJ) is the one of the major mechanisms by which broken DNA strands are repaired.


  • Endosulfan treatment was found to cause “extensive processing of broken DNA” .
  • it՚s leading to increased and long removal in the strands.
  • it՚s also increased the damage by promoting specious repair of the broken DNA strands.
  • Per group five animals were studied and the experiment was repeated many times.

- Published/Last Modified on: August 9, 2016


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