INsT Scientists Develop Simple Economical Nonsurgical Prevention of Cataract (Download PDF)

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INsT Scientists Develop Simple Economical Nonsurgical Prevention of Cataract

  • A team of scientists from the Institute of Nano Science and Technology (INST) has developed nanorods from the nonsteroidal anti-inflammatory drug (NSAID) Aspirin.
  • Aspirin is a popular medication used to reduce pain, fever, or inflammation.
  • Scientists found it to be an effective non-invasive small molecule based nanotherapeutics against cataract.
  • INST is an autonomous institute under the Department of Science and Technology.
Economical Nonsurgical Prevention

Overview

  • Cataract is a major form of blindness.
  • It occurs when the structure of crystalline proteins that make up the lens in our eyes deteriorates.
  • It causes damaged or disorganized proteins to aggregate and form a milky blue or brown layer.
  • The layer thus formed affects lens transparency.
  • Prevention of the formation of these aggregates as well as their destruction in the early stage of disease progression is a major treatment strategy for cataracts.
  • The materials that carry out this task could make cataract prevention affordable and accessible.
  • Aspirin nanorods prevent the aggregation of crystalline protein through bio molecular interactions, which convert beta turn like structure of crystalline peptides, responsible for amyloid formation into coils and helices, those fail to aggregate.
  • These were found to prevent cataract formation by inhibiting aggregation of crystalline and crystalline derived peptide aggregates.
  • With aging and under various conditions, the lens protein crystalline aggregates to form opaque structures in the eye lens, which impairs vision and cause cataract.
  • Though many natural compounds have already been reported as potential aggregation inhibitors for crystalline aggregation, but the utility of NSAIDs will open new paradigm.

Aspirin nanorods, due to their nanosized will enhance

  • Bioavailability
  • Improve drug loading
  • Lower toxicity

Thus, the delivery of aspirin nanorods as eye drops is going to serve as an effective and viable option to treat cataract non-invasively.

- Published/Last Modified on: January 21, 2021

Science/Technology, Economy

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