Nanotechnology-Based Drug Delivery System Developed by All-Women Team of IIT Delhi Researchers (Download PDF)

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All-women team of researchers from IIT Delhi developed a new drug delivery platform based on nanoparticles with ability to boost the efficacy of antibiotics at the cellular level and improve chances of recovery from cancer-related bacterial infections.

Nanotechnology-Based Drug Delivery System

Shortcomings of State of the Art

  • Traditional drug delivery system leaves bacterial infection in cancer untreated infecting the host even after the cancer cells are killed by chemotherapy.
  • Antibiotics used in conventional therapeutics suffer from:
    • Improper bio-distribution
    • Lack of target specificity
    • Poor water solubility
    • Loss of efficacy due to the emergence of drug resistance in pathogenic bacteria
    • 50 % of antibodies either not needed or not effectively utilized.

About New Technology

  • New nanotechnology-based drug delivery system uses sushi-peptide conjugated to gold nanoparticle able to kill E. coli and Salmonella typhi bacteria more efficiently at lower dosages at much lower concentration than free peptides.
  • Nanoconjugate able to kill 50 % of bacteria at much lower concentration (400 nM) while the free peptide՚s antibacterial activity was not significant at the same concentration.
  • The method loads antibiotic drugs on the nanoparticle which can make its way through the bacteria even more deeply making the antibiotic more effective.
  • As the method more effectively eliminates the pathogen, it reduces the chances of antibiotic resistance.
  • Lower dosage also helps reduce the impact of antibiotic on other healthy cells thus reducing side-effects.

- Published/Last Modified on: September 4, 2017

Science/Technology

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