Stem Cell Treatment for More Than 80 Disorders (Important) (Download PDF)

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Stem cells can be used to replace lost or damaged cells that our bodies can’t replace naturally. Cells provide renewable resource for studying normal development & disease & for testing drugs & other therapies.

Image of Types of Stem Cells

Image of Types of Stem Cells

Image of Types of Stem Cells

What Are Stem Cell?

Stem cells are foundation for every organ & tissue in body:

  • Embryonic stem cells exist only at earliest stages of development

  • Tissue-specific stem cells appear during fetal development & remain in human body throughout life.

Stem cells can self-renew & differentiate.

Embryonic Stem Cells

  • Obtained from inner cell mass of blastocyst, mainly hollow ball of cells in human which forms 3 to 5 days after egg cell is fertilized by sperm.

  • Pluripotent means they can give rise to every cell type in fully formed body.

Tissue-Specific Stem Cells

  • Can generate diff. cell types for specific tissue or organ in which they live- example, blood forming stem cells in the bone marrow can give rise to red blood cells, white blood cells and platelets

  • Tissue-specific stem cells can be difficult to find in human body, they do not self-renew in culture.

  • Study of these cells has increased our G. K. about normal development, what changes in aging & what happens with injury & disease.

Mesenchymal Stem Cells

  • Mesenchymal Stem Cells are isolated from stroma, connective tissue that surrounds other tissue & organs.

  • Cells are accurately called ‘stromal cells’.

  • Cells are capable of making bone, cartilage, & fat cells.

Induced Pluripotent Stem Cells

  • Critical tools to help scientists learn more about normal development & disease onset & progression & useful for developing & testing new drugs & therapies.

Why Are Stem Cells Useful?

Stem cells have diff. uses including:

  • Research – to help us understand basic biology of how living things work & what happens in diff. types of cell during disease.

  • Therapy – to replace lost or damaged cells that our bodies can’t replace naturally.

What is Stem Cell Therapy (SCT)?

Image of Six Stages of Stem Cell Therapy

Image of Six Stages of Stem Cell Therapy

Image of Six Stages of Stem Cell Therapy

  • Stem Cell Therapy is treatment of various disorders, non-serious to life threatening, by using stem cells.

  • Stem cells can be procured from different sources to potentially treat more than 80 disorders, including neuromuscular and degenerative disorders.

Disorders Treatable by SCT

  • Hematopoietic disorders like thalassemia, aplastic anemia, storage disorders affect bone marrow & manifest w/various systemic complications.

  • Stem cells from donor are known to reconstitute defective bone marrow & permanently overcome disorder.

  • Degenerative disorders arise from degeneration of bone, cartilage, muscle, fat or other tissue, cell or organ could occur due to variety of reasons, but aging is biggest cause.

  • Disorders have slow & insidious onset but once contracted can be long-standing, pain-staking & lifelong.

  • Disorders can affect any organ of the body.

  • Common degenerative disorders are diabetes, osteoarthritis, stroke, chronic renal failure, congestive cardiac failure, myocardial infarction, Alzheimer’s disease, Parkinson’s disease etc.

Regulation on SCT and SCT Research

  • Indian Council of Medical Research had released ‘Draft Guidelines for Stem Cell Research’ in 2002.

  • Regulation was worked upon along with Department of Biotechnology.

  • As per National Guidelines for Stem Cells Research-2017, only bone marrow stem cell transplantation for blood disorders is permitted use of stem cells.

Institutions Providing SCT

  • All India Institute of Medical Science providing stem cell treatment for cancer & thalassemia patients thru various departments like Dept. of Hematology, Pediatric Oncology, Medical Oncology, Institute Rotary Cancer Hospital & Stem Cell Facility.

  • Tata Memorial Centre, Mumbai is also providing Stem Cell treatment.

- Published/Last Modified on: June 4, 2018

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