Three-Parent Babies Mitochondrial Gene Therapy Allowed by UK Scientists (Download PDF)

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The first baby to be born using a new technique that incorporates DNA from three people. Child born using a controversial “three-parent” baby technique in Mexico. Two women, one man and a baby.

Mitochondrial gene therapy: Two women, one man and a baby

Mitochondrial Gene Therapy: Two Women, One Man and a Baby

Mitochondrial gene therapy: Two women, one man and a baby

  • An independent panel of British scientists and experts has formally given nod to introduce so-called three-parent baby fertility treatments or mitochondrial gene therapy (MGT) procedures.
  • The panel tasked with reviewing the safety of MGT held that this practice cautiously adopted to prevent certain genetic diseases from passed on to future generations. Thus, it paves the way for the country officially introduce the procedures.
  • UK is first country in the world to legalize creation of In-Vitro Fertilization babies with DNA from three people.
  • The world’s first three-parent baby boy was born in Mexico in April 2016 to a Jordanian couple with help of this new fertility technique, which incorporates DNA from three people in embryo.

Mitochondrial Therapy

  • Defective mitochondria carried by a woman replaced with the healthy mitochondria of a donor in a medical technique.
  • Through invitro fertilization technique (IVF), the egg then fertilized with the partner’s sperm. Thus, the embryo remains free from any such genetic defects.
  • It prevents the transmission of mitochondrial (genetic) disease from one generation to the next.
  • The two most common techniques in mitochondrial donation as follows:

    • Maternal spindle transfer
    • Pronuclear transfer
  • This method proposes to give parents chance of having a child that is over 99% genetically matched to them and most importantly free of the mitochondrial disease.

- Published/Last Modified on: December 2, 2016

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