Vaccine Storage & Delivery – Pfizer Model YouTube Lecture Handouts

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Vaccine Storage & Delivery – Pfizer Model

Vaccine Storage & Delivery
  • Distribution approach will be to largely ship from Kalamazoo, Michigan, site direct to the point of use (POU) . Along with existing distribution, center in Pleasant Prairie, Wisconsin.
  • Pfizer manufactures more than 200 million doses of Pfizer vaccines annually and is one of the largest sterile injectable suppliers in the world, producing more than 1 billion sterile units per year.
  • Distribution is built on a flexible, just-in-time system, which will ship the frozen vials direct to the point of vaccination.
Vaccine Storage & Delivery
  • 5 dose per vial
  • 195 vials per tray
  • 5 trays per box
  • Box stuffed with dry ice
  • GPS enabled sensors to monitor location and temperature
  • Specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain storage temperature conditions of for up to 10 days unopened. Ultra-low-temperature freezers, which are commercially available and can, extend shelf life for up to six months.
  • The Pfizer thermal shippers, in which doses will arrive, that can be used as temporary storage units by refilling with dry ice every five days for up to 30 days of storage.
  • Refrigeration units that is commonly available in hospitals. The vaccine can be stored for five days at refrigerated conditions.
  • After storage for up to 30 days in the Pfizer thermal shipper, vaccination centers can transfer the vials to storage conditions for an additional five days, for a total of up to 35 days. Once thawed and stored under conditions, the vials cannot be re-frozen or stored under frozen conditions.

Dry Ice

Dry Ice is the Solid Form of Carbon Dioxide
  • Dry ice is the solid form of carbon dioxide. It is used primarily as a cooling agent, but is also used in fog machines at theatres for dramatic effects
  • Dry ice sublimes at 194.7 K or () at Earth atmospheric pressure. This extreme cold makes the solid dangerous to handle without protection due to burns caused by freezing (frostbite) . While generally not very toxic, the outgassing from it can cause hypercapnia (abnormally elevated carbon dioxide levels in the blood) due to buildup in confined locations.
  • At pressures below 5.13 atm and temperatures below (the triple point) , changes from a solid to a gas with no intervening liquid form, through a process called sublimation.
  • Dry ice can be used as bait to trap mosquitoes, bedbugs, and other insects, due to their attraction to carbon dioxide